Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19974516 | 1.00 | LMNA (0.55) | LMNAMAPTHTTRAB9ASMN1; SMN2 | |
| SCHEMBL19974171 | 0.76 | RAB9A (0.54) | LMNAMAPTHTTRAB9ASMN1; SMN2 | |
| SCHEMBL19974169 | 0.76 | RAB9A (0.54) | LMNAMAPTHTTRAB9ASMN1; SMN2 | |
| SCHEMBL19974162 | 0.75 | LMNA (0.65) | LMNAMAPTHTTRAB9ASMN1; SMN2 | |
| SCHEMBL23657167 | 0.75 | MAPT (0.77) | LMNAMAPTHTTRAB9ASMN1; SMN2 | |
| SCHEMBL19974421 | 0.74 | LMNA (0.68) | LMNAMAPTHTTRAB9ASMN1; SMN2 | |
| SCHEMBL32690316 | 0.74 | RAB9A (0.66) | LMNAMAPTHTTRAB9ASMN1; SMN2 | |
| SCHEMBL19974151 | 0.74 | RAB9A (0.66) | LMNAMAPTHTTRAB9ASMN1; SMN2 | |
| SCHEMBL19974134 | 0.74 | RAB9A (0.66) | LMNAMAPTHTTRAB9ASMN1; SMN2 | |
| SCHEMBL19974517 | 0.73 | L3MBTL1 (0.73) | LMNAMAPTHTTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512602-A2 | INHIBITORS OF HEAT SHOCK FACTORS AND USES THEREOF | HSF Pharmaceuticals (CH) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018050656-A2 | INHIBITORS OF HEAT SHOCK FACTORS AND USES THEREOF | HSF PHARMACEUTICALS (CH) | 2018-03-22 | — | — | WO | disclosed |