SCHEMBL19974685

SCHEMBL19974685

COc1ccccc1N(C=O)C(C)C(=O)C(=O)NCc1ccncc1

nearest known ligand 0.51

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.51
LMNA P02545 4/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
RAB9A P51151 1/20 0.44
ALDH1A1 P00352 5/20 0.43
NAMPT P43490 6/20 0.42
CYP3A4 P08684 1/20 0.41
CTSK P43235 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19975219 0.91 LMNA (0.47) LMNASMN1; SMN2RAB9AALDH1A1CYP3A4
SCHEMBL21176346 0.89 ALDH1A1 (0.56) POLBLMNASMN1; SMN2ALDH1A1CYP3A4
SCHEMBL19974712 0.88 CARM1 (0.45) LMNARAB9AALDH1A1
SCHEMBL19975281 0.88 ALDH1A1 (0.45) POLBLMNARAB9AALDH1A1
SCHEMBL28315333 0.85 CAPN1 (0.39) LMNARAB9AALDH1A1CYP3A4
SCHEMBL21183552 0.85 HPGD (0.51) POLBRAB9AALDH1A1
SCHEMBL21183553 0.84 HPGD (0.54) POLBSMN1; SMN2RAB9AALDH1A1CTSK
SCHEMBL19975394 0.84 TACR1 (0.39) LMNARAB9AALDH1A1CYP3A4
SCHEMBL19974837 0.84 HPGD (0.43) POLBLMNASMN1; SMN2ALDH1A1NAMPT
SCHEMBL21183556 0.84 ADORA2A (0.43) POLBLMNARAB9AALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220356148-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2022-11-10 US disclosed
US-11091428-B2 Antiviral compounds HAPLOGEN GMBH (AT) 2021-08-17 US disclosed
US-11091428-B2 Antiviral compounds HAPLOGEN GMBH (AT) 2021-08-17 US disclosed
CN-110062753-A Antiviral compounds 哈普洛根有限责任公司 2019-07-26 CN disclosed
US-20190225575-A1 ANTIVIRAL COMPOUNDS LUNIS CONSULTING GMBH (AT) 2019-07-25 US disclosed
US-20190225575-A1 ANTIVIRAL COMPOUNDS LUNIS CONSULTING GMBH (AT) 2019-07-25 US disclosed
EP-3512836-A1 ANTIVIRAL COMPOUNDS Haplogen GmbH (AT) 2019-07-24 EP disclosed
WO-2018050631-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2018-03-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190225575-A1 ANTIVIRAL COMPOUNDS PLA2G1B, PLA2G12A, PLA2G4C POLB 833/4885LMNA 1909/4885SMN1; SMN2 706/4885
US-20220356148-A1 ANTIVIRAL COMPOUNDS PLA2G12A, PLA2G1B, PLA2G4C POLB 617/4885LMNA 2058/4885SMN1; SMN2 1086/4885
US-11091428-B2 Antiviral compounds PLA2G1B, PLA2G12A, PLA2G4C POLB 833/4885LMNA 1909/4885SMN1; SMN2 706/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.