SCHEMBL19974779

SCHEMBL19974779

COc1ccccc1N(C=O)C(C)C(=O)C(=O)NCc1ccccc1C

nearest known ligand 0.48

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.46
POLB P06746 3/20 0.46
MEN1 O00255 3/20 0.46
LMNA P02545 2/20 0.46
HPGD P15428 5/20 0.43
HTT P42858 1/20 0.43
GAA P10253 1/20 0.42
KDM4E B2RXH2 1/20 0.41
TSHR P16473 1/20 0.41
ALDH1A1 P00352 3/20 0.40
CHRM2 P08172 1/20 0.40
MAPT P10636 2/20 0.39
BLM P54132 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21183552 0.92 HPGD (0.51) KMT2APOLBMEN1HPGDHTT
SCHEMBL19974718 0.89 HPGD (0.39) KMT2APOLBMEN1LMNAHPGD
SCHEMBL28876095 0.88 HPGD (0.42) KMT2APOLBMEN1HPGDHTT
SCHEMBL21183551 0.88 MAPT (0.54) KMT2APOLBMEN1HPGDHTT
SCHEMBL19975219 0.86 LMNA (0.47) KMT2AMEN1LMNAHPGDGAA
SCHEMBL28315333 0.84 CAPN1 (0.39) KMT2AMEN1LMNAHPGDGAA
SCHEMBL19975096 0.83 HPGD (0.47) KMT2AMEN1HPGDHTTALDH1A1
SCHEMBL19974712 0.83 CARM1 (0.45) LMNAKDM4EALDH1A1MAPT
SCHEMBL21183556 0.82 ADORA2A (0.43) POLBLMNAHPGDHTTGAA
SCHEMBL19975281 0.82 ALDH1A1 (0.45) KMT2APOLBMEN1LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220356148-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2022-11-10 US disclosed
US-11091428-B2 Antiviral compounds HAPLOGEN GMBH (AT) 2021-08-17 US disclosed
US-11091428-B2 Antiviral compounds HAPLOGEN GMBH (AT) 2021-08-17 US disclosed
US-20190225575-A1 ANTIVIRAL COMPOUNDS LUNIS CONSULTING GMBH (AT) 2019-07-25 US disclosed
US-20190225575-A1 ANTIVIRAL COMPOUNDS LUNIS CONSULTING GMBH (AT) 2019-07-25 US disclosed
EP-3512836-A1 ANTIVIRAL COMPOUNDS Haplogen GmbH (AT) 2019-07-24 EP disclosed
WO-2018050631-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2018-03-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190225575-A1 ANTIVIRAL COMPOUNDS PLA2G1B, PLA2G12A, PLA2G4C KMT2A 4031/4885POLB 833/4885MEN1 4331/4885
US-20220356148-A1 ANTIVIRAL COMPOUNDS PLA2G12A, PLA2G1B, PLA2G4C KMT2A 4177/4885POLB 617/4885MEN1 4361/4885
US-11091428-B2 Antiviral compounds PLA2G1B, PLA2G12A, PLA2G4C KMT2A 4031/4885POLB 833/4885MEN1 4331/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.