SCHEMBL19974867

SCHEMBL19974867

O=C(O)C(=O)[C@H]1CCC(=O)N1Cc1ccc(Cl)cc1

nearest known ligand 0.57

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.54
P2RX7 Q99572 7/20 0.52
KMT2A Q03164 2/20 0.51
GAA P10253 2/20 0.49
MAPT P10636 2/20 0.46
HTT P42858 2/20 0.46
LMNA P02545 1/20 0.46
MEN1 O00255 1/20 0.46
HCRTR1 O43613 1/20 0.45
HCRTR2 O43614 1/20 0.45
TP53 P04637 1/20 0.44
MDM2 Q00987 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19975238 1.00 ALDH1A1 (0.54) ALDH1A1P2RX7KMT2AGAAMAPT
SCHEMBL19975206 0.88 P2RX7 (0.54) ALDH1A1P2RX7KMT2AGAAMAPT
SCHEMBL16601331 0.88 P2RX7 (0.54) ALDH1A1P2RX7KMT2AGAAMAPT
SCHEMBL19974905 0.88 P2RX7 (0.54) ALDH1A1P2RX7KMT2AGAAMAPT
SCHEMBL19975186 0.88 P2RX7 (0.54) ALDH1A1P2RX7KMT2AGAAMAPT
SCHEMBL10408410 0.88 P2RX7 (0.54) ALDH1A1P2RX7KMT2AGAAMAPT
SCHEMBL19975137 0.88 P2RX7 (0.54) ALDH1A1P2RX7KMT2AGAAMAPT
SCHEMBL21183520 0.87 GAA (0.56) ALDH1A1P2RX7KMT2AGAAHTT
SCHEMBL19975021 0.87 KMT2A (0.67) ALDH1A1KMT2AGAAMAPTHTT
SCHEMBL19974972 0.85 P2RX7 (0.56) ALDH1A1P2RX7KMT2AGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220356148-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2022-11-10 US disclosed
US-11091428-B2 Antiviral compounds HAPLOGEN GMBH (AT) 2021-08-17 US disclosed
US-11091428-B2 Antiviral compounds HAPLOGEN GMBH (AT) 2021-08-17 US disclosed
US-20190225575-A1 ANTIVIRAL COMPOUNDS LUNIS CONSULTING GMBH (AT) 2019-07-25 US disclosed
US-20190225575-A1 ANTIVIRAL COMPOUNDS LUNIS CONSULTING GMBH (AT) 2019-07-25 US disclosed
EP-3512836-A1 ANTIVIRAL COMPOUNDS Haplogen GmbH (AT) 2019-07-24 EP disclosed
WO-2018050631-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2018-03-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190225575-A1 ANTIVIRAL COMPOUNDS PLA2G1B, PLA2G12A, PLA2G4C ALDH1A1 2271/4885P2RX7 339/4885KMT2A 4031/4885
US-20220356148-A1 ANTIVIRAL COMPOUNDS PLA2G12A, PLA2G1B, PLA2G4C ALDH1A1 2673/4885P2RX7 564/4885KMT2A 4177/4885
US-11091428-B2 Antiviral compounds PLA2G1B, PLA2G12A, PLA2G4C ALDH1A1 2271/4885P2RX7 339/4885KMT2A 4031/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.