SCHEMBL19974873

SCHEMBL19974873

CC(NC(=O)c1ccccc1Cl)C(=O)C(=O)NCC1CC1

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.48
CNR2 P34972 2/20 0.47
P2RX7 Q99572 2/20 0.47
CNR1 P21554 1/20 0.47
GPR139 Q6DWJ6 1/20 0.45
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
ALDH1A1 P00352 2/20 0.44
KMT2A Q03164 1/20 0.44
CHRM1 P11229 1/20 0.44
KDM4E B2RXH2 1/20 0.44
GAA P10253 1/20 0.44
RECQL P46063 1/20 0.43
HTT P42858 1/20 0.43
LMNA P02545 1/20 0.43
KCNK3 O14649 1/20 0.43
HPGD P15428 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19975398 0.86 MAPK14 (0.43) P2RX7NPC1RAB9AKMT2AHPGD
SCHEMBL19974990 0.86 MAPK14 (0.43) P2RX7NPC1RAB9AKMT2AHPGD
SCHEMBL19974847 0.86 P2RX7 (0.44) CNR2P2RX7CNR1NPC1RAB9A
SCHEMBL19974989 0.86 MAPK14 (0.43) P2RX7NPC1RAB9AKMT2AHPGD
SCHEMBL19974684 0.85 POLB (0.46) SMN1; SMN2NPC1RAB9AALDH1A1KMT2A
SCHEMBL19974800 0.85 SMN1; SMN2 (0.53) SMN1; SMN2P2RX7ALDH1A1KMT2AKDM4E
SCHEMBL19975132 0.83 HPGD (0.50) SMN1; SMN2P2RX7NPC1RAB9AALDH1A1
SCHEMBL21176278 0.82 PREP (0.47) SMN1; SMN2RAB9AALDH1A1KDM4EHPGD
SCHEMBL21183565 0.80 RAB9A (0.47) SMN1; SMN2P2RX7NPC1RAB9AALDH1A1
SCHEMBL2129927 0.80 CHRM1 (0.61) CNR2P2RX7CNR1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220356148-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2022-11-10 US disclosed
US-11091428-B2 Antiviral compounds HAPLOGEN GMBH (AT) 2021-08-17 US disclosed
CN-110062753-A Antiviral compounds 哈普洛根有限责任公司 2019-07-26 CN disclosed
US-20190225575-A1 ANTIVIRAL COMPOUNDS LUNIS CONSULTING GMBH (AT) 2019-07-25 US disclosed
EP-3512836-A1 ANTIVIRAL COMPOUNDS Haplogen GmbH (AT) 2019-07-24 EP disclosed
WO-2018050631-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2018-03-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190225575-A1 ANTIVIRAL COMPOUNDS PLA2G1B, PLA2G12A, PLA2G4C SMN1; SMN2 706/4885CNR2 2339/4885P2RX7 339/4885
US-20220356148-A1 ANTIVIRAL COMPOUNDS PLA2G12A, PLA2G1B, PLA2G4C SMN1; SMN2 1086/4885CNR2 2681/4885P2RX7 564/4885
US-11091428-B2 Antiviral compounds PLA2G1B, PLA2G12A, PLA2G4C SMN1; SMN2 706/4885CNR2 2339/4885P2RX7 339/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.