Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 5/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976771 | 0.89 | GSK3B (0.46) | GSK3BFGFR1FGFR2FGFR3MAP2K4 | |
| SCHEMBL19976744 | 0.87 | GSK3B (0.45) | GSK3BFGFR1FGFR2FGFR3MAP2K4 | |
| SCHEMBL19976820 | 0.85 | HDAC6 (0.46) | GSK3BMAP2K4HDAC6GSK3ACYP1A2 | |
| SCHEMBL19976745 | 0.83 | GSK3B (0.45) | GSK3BFGFR1FGFR2FGFR3MAP2K4 | |
| SCHEMBL19976765 | 0.81 | NTRK1 (0.41) | GSK3BMAP2K4HDAC6GSK3APIM1 | |
| SCHEMBL16752823 | 0.81 | MAP2K4 (0.44) | GSK3BFGFR1FGFR2FGFR3MAP2K4 | |
| SCHEMBL16752817 | 0.81 | MAP2K4 (0.44) | GSK3BFGFR1FGFR2FGFR3MAP2K4 | |
| SCHEMBL16752820 | 0.81 | MAP2K4 (0.44) | GSK3BFGFR1FGFR2FGFR3MAP2K4 | |
| SCHEMBL16769269 | 0.81 | MAP2K4 (0.44) | GSK3BFGFR1FGFR2FGFR3MAP2K4 | |
| SCHEMBL16675964 | 0.79 | GSK3B (0.49) | GSK3BHDAC6GSK3APIK3CDPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |