Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.46 |
| ▸ | GSK3B | P49841 | 8/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | FADS1 | O60427 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976771 | 0.90 | GSK3B (0.46) | HDAC6GSK3BGSK3AMAP2K4CYP1A2 | |
| SCHEMBL19976787 | 0.88 | HDAC6 (0.43) | HDAC6GSK3BGSK3AMAPK8MAPK10 | |
| SCHEMBL19976821 | 0.85 | HDAC6 (0.44) | HDAC6GSK3BGSK3AMAPK8MAPK10 | |
| SCHEMBL19976747 | 0.85 | GSK3B (0.45) | HDAC6GSK3BGSK3AMAP2K4CYP1A2 | |
| SCHEMBL19976741 | 0.83 | MAPK1 (0.44) | HDAC6GSK3BGSK3AMAPK8MAPK10 | |
| SCHEMBL19976765 | 0.80 | NTRK1 (0.41) | HDAC6GSK3BGSK3AMAPK8MAP2K4 | |
| SCHEMBL18558653 | 0.79 | IDO1 (0.39) | HDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL19976730 | 0.79 | HDAC6 (0.41) | HDAC6GSK3BGSK3AMAPK8MAPK10 | |
| SCHEMBL19976725 | 0.78 | GSK3B (0.52) | HDAC6GSK3BMAPK8MAPK10MAP2K4 | |
| SCHEMBL19976859 | 0.78 | GSK3B (0.45) | HDAC6GSK3BGSK3AMAP2K4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |