Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 6/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.38 |
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CLK2 | P49760 | 3/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976736 | 0.90 | MAP2K4 (0.44) | NTRK1JAK2GSK3BDAPK3MAP4K4 | |
| SCHEMBL19976730 | 0.89 | HDAC6 (0.41) | JAK2GSK3BDAPK3MAP4K4PIM1 | |
| SCHEMBL19976866 | 0.84 | DYRK1A (0.42) | NTRK1GSK3BDAPK3MAP4K4PIM1 | |
| SCHEMBL19976725 | 0.84 | GSK3B (0.52) | GSK3BDYRK1AMAPK8MAPKAPK5HDAC6 | |
| SCHEMBL19976726 | 0.82 | ABL1 (0.41) | NTRK1JAK2GSK3BDAPK3MAP4K4 | |
| SCHEMBL19976801 | 0.82 | TRPA1 (0.37) | JAK2GSK3BDAPK3MAP4K4PIM1 | |
| SCHEMBL19976802 | 0.82 | KDR (0.36) | JAK2CDK2DYRK1AFLT4FLT3 | |
| SCHEMBL19976929 | 0.82 | RIPK1 (0.37) | JAK2DYRK1AAURKBHDAC6AURKA | |
| SCHEMBL19976747 | 0.81 | GSK3B (0.45) | GSK3BPIM1CDK2HDAC6GSK3A | |
| SCHEMBL19976820 | 0.80 | HDAC6 (0.46) | GSK3BMAPK8FADS1HDAC6GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |