Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.38 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.35 |
| ▸ | FADS1 | O60427 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976734 | 0.88 | MAPK10 (0.36) | GSK3BMAPK1MAPK8MAPK10HDAC6 | |
| SCHEMBL19976800 | 0.84 | GSK3B (0.43) | MAP2K4GSK3BMAPK1MAPKAPK3MAPK6 | |
| SCHEMBL19976854 | 0.84 | GSK3B (0.42) | MAP2K4GSK3BMAPK1MAPKAPK3MAPK6 | |
| SCHEMBL19976736 | 0.82 | MAP2K4 (0.44) | MAP2K4GSK3BMAPK1MAPKAPK3MAPK6 | |
| SCHEMBL19976815 | 0.81 | GSK3B (0.44) | MAP2K4GSK3BMAPK1MAPKAPK3MAPK6 | |
| SCHEMBL19976888 | 0.77 | GSK3B (0.51) | MAP2K4GSK3BMAPK1MAPK6TRPA1 | |
| SCHEMBL19976767 | 0.77 | GSK3B (0.51) | MAP2K4GSK3BMAPK1MAPK6TRPA1 | |
| SCHEMBL19976812 | 0.75 | GSK3B (0.51) | MAP2K4GSK3BMAPK1MAPK6TRPA1 | |
| SCHEMBL18558609 | 0.75 | HDAC3 (0.38) | HDAC6NTRK1MAPT | |
| SCHEMBL19976725 | 0.75 | GSK3B (0.52) | MAP2K4GSK3BMAPK1MAPKAPK3MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |