Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 14/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 10/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | MARK3 | P27448 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976762 | 0.88 | MAP2K4 (0.40) | MAPK10MAPK8HDAC6NTRK1GSK3B | |
| SCHEMBL19976846 | 0.82 | KDM4E (0.42) | MAPK10MAPK8HDAC6ABL1BCR | |
| SCHEMBL19976757 | 0.82 | HDAC6 (0.39) | MAPK10MAPK8HDAC6ABL1BCR | |
| SCHEMBL19976731 | 0.79 | MAPK1 (0.42) | MAPK8HDAC6NTRK1ABL1BCR | |
| SCHEMBL19976730 | 0.79 | HDAC6 (0.41) | MAPK10MAPK8HDAC6PLK4MAPK13 | |
| SCHEMBL18558609 | 0.78 | HDAC3 (0.38) | HDAC6NTRK1NAMPT | |
| SCHEMBL19976866 | 0.73 | DYRK1A (0.42) | MAPK8NTRK1PLK4MAPK13DAPK3 | |
| SCHEMBL19976776 | 0.72 | GSK3B (0.48) | HDAC6GSK3BDYRK1AMAPK1 | |
| SCHEMBL19976886 | 0.72 | GSK3B (0.43) | HDAC6GSK3BMAPK1 | |
| SCHEMBL19976857 | 0.71 | MAPK1 (0.35) | MAPK8HDAC6ABL1BCRPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |