Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976929 | 0.85 | RIPK1 (0.37) | HDAC6TRPV1RIPK1AURKAAURKB | |
| SCHEMBL18558644 | 0.79 | TRPV1 (0.38) | HDAC6TRPV1GSK3B | |
| SCHEMBL9920889 | 0.76 | HDAC6 (0.37) | HDAC6TRPV1GSK3B | |
| SCHEMBL9921034 | 0.74 | HDAC6 (0.39) | HDAC6TRPV1GSK3BTLR7 | |
| SCHEMBL18558594 | 0.74 | HDAC6 (0.39) | HDAC6TRPV1GSK3B | |
| SCHEMBL19976725 | 0.74 | GSK3B (0.52) | HDAC6GSK3BMAPK10 | |
| SCHEMBL19976736 | 0.74 | MAP2K4 (0.44) | HDAC6GSK3BMAPK10AURKAAURKB | |
| SCHEMBL18558030 | 0.73 | GRM5 (0.41) | TRPV1GSK3BAURKB | |
| SCHEMBL9905332 | 0.73 | P2RY14 (0.38) | HDAC6TRPV1TLR7 | |
| SCHEMBL9905327 | 0.73 | P2RY14 (0.38) | HDAC6TRPV1TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |