Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9920889 | 0.84 | HDAC6 (0.37) | TRPV1HDAC6GSK3BMCHR1P2RY14 | |
| SCHEMBL18557806 | 0.82 | ALOX15 (0.46) | HDAC6 | |
| SCHEMBL18557800 | 0.80 | P2RX7 (0.43) | — | |
| SCHEMBL19976852 | 0.79 | HDAC6 (0.40) | TRPV1HDAC6GSK3B | |
| SCHEMBL9921034 | 0.77 | HDAC6 (0.39) | TRPV1HDAC6GSK3BCES2CES1 | |
| SCHEMBL18558594 | 0.77 | HDAC6 (0.39) | TRPV1HDAC6GSK3BCES2CES1 | |
| SCHEMBL9905332 | 0.75 | P2RY14 (0.38) | TRPV1HDAC6CES2CES1P2RY14 | |
| SCHEMBL9905327 | 0.75 | P2RY14 (0.38) | TRPV1HDAC6CES2CES1P2RY14 | |
| SCHEMBL18558075 | 0.75 | SNCA (0.37) | TRPV1HDAC6P2RY14MAP2K4PRKAB2 | |
| SCHEMBL9920926 | 0.75 | RAB9A (0.53) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580388-B2 | Pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2017-02-28 | — | — | US | disclosed |