Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19978789 | 1.00 | GPR119 (0.37) | GPR119JAK3NAMPTNR1H2HPGD | |
| SCHEMBL22032685 | 0.79 | NR1H2 (0.41) | GPR119NAMPTNR1H2ESR2USP2 | |
| SCHEMBL22032711 | 0.73 | NAMPT (0.39) | GPR119NAMPTNR1H2ESR2USP2 | |
| SCHEMBL19978897 | 0.72 | GPR119 (0.36) | GPR119JAK3NAMPTNR1H2USP2 | |
| SCHEMBL19972951 | 0.72 | NFKB1 (0.37) | GPR119JAK3NR1H2NFKB1NFKB2 | |
| SCHEMBL19972948 | 0.72 | NFKB1 (0.37) | GPR119JAK3NR1H2NFKB1NFKB2 | |
| SCHEMBL19972949 | 0.72 | NFKB1 (0.37) | GPR119JAK3NR1H2NFKB1NFKB2 | |
| SCHEMBL19978889 | 0.71 | NR1H2 (0.37) | JAK3NR1H2HPGDKDM4ENFKB1 | |
| SCHEMBL19972965 | 0.71 | NR1H2 (0.37) | JAK3NR1H2HPGDKDM4ENFKB1 | |
| SCHEMBL1257642 | 0.68 | USP2 (0.43) | GPR119NAMPTNR1H2ESR2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512851-B1 | BETA-LACTAMASE INHIBITOR COMPOUNDS | ENTASIS THERAPEUTICS LTD (GB) | 2022-07-06 | — | — | EP | disclosed |
| WO-2018053215-A1 | BETA-LACTAMASE INHIBITOR COMPOUNDS | ENTASIS THERAPEUTICS LIMITED (GB) | 2018-03-22 | — | — | WO | disclosed |