Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19759343 | 0.77 | NR1H2 (0.41) | GPR119NR1H2MAPTPDK4USP2 | |
| SCHEMBL19978893 | 0.73 | NFKB1 (0.32) | GPR119DDB1CRBNNR1H2JAK3 | |
| SCHEMBL19978859 | 0.72 | GPR119 (0.37) | GPR119NR1H2MAPTALDH1A1MAPK1 | |
| SCHEMBL19978789 | 0.72 | GPR119 (0.37) | GPR119NR1H2MAPTALDH1A1MAPK1 | |
| SCHEMBL24493585 | 0.70 | KDM4E (0.42) | GPR119NR1H2MAPTPDK4USP2 | |
| SCHEMBL21135638 | 0.69 | NR1H2 (0.41) | GPR119NR1H2MAPTMAPK1PDK4 | |
| SCHEMBL31045555 | 0.69 | HSD17B10 (0.41) | GPR119NR1H2MAPTALDH1A1USP2 | |
| SCHEMBL16052286 | 0.68 | NR1H2 (0.40) | GPR119NR1H2MAPTMAPK1PDK4 | |
| SCHEMBL16052666 | 0.68 | USP30 (0.40) | GPR119NR1H2MAPTMAPK1PDK4 | |
| SCHEMBL16052285 | 0.68 | NR1H2 (0.40) | GPR119NR1H2MAPTMAPK1PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053215-A1 | BETA-LACTAMASE INHIBITOR COMPOUNDS | ENTASIS THERAPEUTICS LIMITED (GB) | 2018-03-22 | — | — | WO | disclosed |