Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21156955 | 0.75 | KDM4E (0.46) | KDM4EKMT2AALDH1A1MEN1L3MBTL1 | |
| SCHEMBL25620241 | 0.74 | KDM4E (0.50) | KDM4EKMT2AALDH1A1MEN1L3MBTL1 | |
| SCHEMBL10194479 | 0.74 | CTBP2 (0.67) | KMT2AMEN1CTBP2CES2CES1 | |
| SCHEMBL19246183 | 0.69 | L3MBTL1 (0.50) | KMT2AALDH1A1MEN1L3MBTL1CYP3A4 | |
| SCHEMBL15648386 | 0.67 | ALDH1A1 (0.50) | KDM4EKMT2AALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL15648384 | 0.67 | ALDH1A1 (0.50) | KDM4EKMT2AALDH1A1SMN1; SMN2RECQL | |
| Acetone SCHEMBL7728200 | 0.67 | L3MBTL1 (0.56) | KDM4EKMT2AALDH1A1MEN1L3MBTL1 | |
| SCHEMBL19825334 | 0.67 | NOS2 (0.50) | KDM4EKMT2AALDH1A1MEN1L3MBTL1 | |
| SCHEMBL107900 | 0.66 | L3MBTL1 (0.59) | KMT2AALDH1A1MEN1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7628959 | 0.65 | CES1 (0.48) | KMT2AALDH1A1MEN1L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |