Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20344668 | 0.87 | CES2 (0.39) | KMT2AMEN1L3MBTL1HPGDCNR2 | |
| SCHEMBL23189256 | 0.83 | HPGD (0.42) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL22710318 | 0.73 | CES1 (0.40) | KMT2AMEN1ALDH1A1L3MBTL1HPGD | |
| SCHEMBL10880029 | 0.72 | CTBP2 (0.46) | RAB9ANPC1KMT2AL3MBTL1MAPK8 | |
| SCHEMBL658518 | 0.69 | CA2 (0.67) | RAB9ANPC1ALDH1A1L3MBTL1MAPK8 | |
| SCHEMBL171860 | 0.68 | HPGD (0.59) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL22059363 | 0.68 | HPGD (0.42) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL24386036 | 0.67 | IDO1 (0.47) | RAB9ANPC1L3MBTL1MAPK8HPGD | |
| SCHEMBL19980208 | 0.66 | ALDH1A1 (0.40) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL20344509 | 0.65 | CES1 (0.45) | KMT2AMEN1ALDH1A1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |