Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.38 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 2/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.35 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7121445 | 0.86 | ABCC9 (0.48) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL7398707 | 0.79 | TSHR (0.40) | TSHRHSD17B10DRD2DRD3MEN1 | |
| SCHEMBL22887810 | 0.79 | CTRC (0.37) | MEN1KMT2A | |
| SCHEMBL10441821 | 0.74 | TSHR (0.44) | TSHRHSD17B10DRD2DRD3MEN1 | |
| SCHEMBL14390806 | 0.74 | CYP3A4 (0.44) | TSHR | |
| SCHEMBL19597024 | 0.74 | TSHR (0.41) | TSHRHSD17B10DRD2DRD3MEN1 | |
| SCHEMBL4767252 | 0.73 | TSHR (0.42) | TSHRHSD17B10DRD2DRD3MEN1 | |
| SCHEMBL10465908 | 0.73 | TYR (0.47) | TSHRHSD17B10DRD2DRD3MEN1 | |
| SCHEMBL2693347 | 0.72 | MEN1 (0.43) | ABCC9ABCC8KCNJ11KCNJ8TSHR | |
| SCHEMBL23287027 | 0.72 | TYR (0.46) | TSHRHSD17B10DRD2DRD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |