Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29952696 | 0.85 | CYP2A6 (0.44) | RAD51MEN1KMT2ACYP2A6 | |
| SCHEMBL1859259 | 0.85 | CYP2A6 (0.44) | RAD51MEN1KMT2ACYP2A6 | |
| SCHEMBL19980262 | 0.79 | ABCC9 (0.38) | TSHRHSD17B10DRD2DRD3MEN1 | |
| SCHEMBL11759112 | 0.77 | ALDH1A3 (0.40) | TSHRHSD17B10EGFRTLR8TYR | |
| SCHEMBL31056287 | 0.77 | SRC (0.47) | TLR7TLR8TYR | |
| SCHEMBL13913074 | 0.77 | RAD51 (0.39) | RAD51CYP2A6 | |
| SCHEMBL8649664 | 0.77 | CDK1 (0.46) | TSHRHSD17B10TLR8 | |
| SCHEMBL10441821 | 0.77 | TSHR (0.44) | TSHRHSD17B10DRD2DRD3MEN1 | |
| SCHEMBL9471487 | 0.77 | TLR8 (0.41) | MEN1KMT2ATLR7TLR8TYR | |
| SCHEMBL10465908 | 0.76 | TYR (0.47) | TSHRHSD17B10DRD2DRD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5863947-A | Phenylglycine derivatives useful for treating disorders of the central nervous system | ELI LILLY AND COMPANY LIMITED (GB) | 1999-01-26 | — | — | US | disclosed |
| EP-0807621-A1 | Derivatives of phenylglycine and use thereof as pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1997-11-19 | — | — | EP | disclosed |