Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30265918 | 1.00 | DRD2 (0.39) | DRD2NPY5ROPRM1OPRK1OPRL1 | |
| SCHEMBL21141077 | 1.00 | DRD2 (0.39) | DRD2NPY5ROPRM1OPRK1OPRL1 | |
| SCHEMBL30265699 | 1.00 | DRD2 (0.39) | DRD2NPY5ROPRM1OPRK1OPRL1 | |
| SCHEMBL19980545 | 0.95 | DRD3 (0.39) | DRD2NPY5R | |
| SCHEMBL30265747 | 0.95 | DRD3 (0.39) | DRD2NPY5R | |
| SCHEMBL30265904 | 0.94 | NPY5R (0.41) | NPY5RLMNATP53 | |
| SCHEMBL19980698 | 0.94 | NPY5R (0.41) | NPY5RLMNATP53 | |
| SCHEMBL19972513 | 0.91 | HTR2A (0.40) | DRD2NPY5ROPRM1OPRK1OPRL1 | |
| SCHEMBL19980669 | 0.91 | HTR2A (0.40) | DRD2NPY5ROPRM1OPRK1OPRL1 | |
| SCHEMBL19972578 | 0.91 | OPRM1 (0.38) | NPY5ROPRM1OPRK1OPRL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4230627-A2 | INHIBITORS OF THE MENIN-MLL INTERACTION | Vitae Pharmaceuticals, LLC (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-3512850-B1 | INHIBITORS OF THE MENIN-MLL INTERACTION | VITAE PHARMACEUTICALS LLC (US) | 2023-04-12 | — | — | EP | disclosed |
| WO-2018053267-A1 | INHIBITORS OF THE MENIN-MLL INTERACTION | VITAE PHARMACEUTICALS, INC. (US) | 2018-03-22 | — | — | WO | disclosed |