SCHEMBL1998118

SCHEMBL1998118

O=COc1cc(C(F)(F)F)ccc1C(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.46
KDM4E B2RXH2 2/20 0.38
ALDH1A1 P00352 2/20 0.38
HPGD P15428 2/20 0.38
HSD17B10 Q99714 2/20 0.38
USP2 O75604 1/20 0.38
CYP2C19 P33261 1/20 0.38
RXRA P19793 1/20 0.36
RXRB P28702 1/20 0.36
RXRG P48443 1/20 0.36
FFAR4 Q5NUL3 1/20 0.36
KIF11 P52732 1/20 0.34
SRD5A2 P31213 1/20 0.34
CYP26A1 O43174 1/20 0.34
CYP24A1 Q07973 1/20 0.34
ESRRA P11474 1/20 0.34
PTGS1 P23219 2/20 0.33
HTR1A P08908 1/20 0.33
DRD2 P14416 1/20 0.33
HTR2A P28223 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1758894 0.80 CYP2C19 (0.41) KDM4EALDH1A1HPGDHSD17B10USP2
SCHEMBL25836655 0.76 MEN1 (0.41) CES2KDM4EALDH1A1HPGDHSD17B10
SCHEMBL1996546 0.75 PPARG (0.41) ALDH1A1RXRARXRBRXRGESRRA
SCHEMBL15453988 0.74 CES2 (0.55) CES2KDM4EALDH1A1HPGDHSD17B10
SCHEMBL28281433 0.73 MASP2 (0.56) ALDH1A1HPGDESRRA
SCHEMBL28549368 0.72 CES2 (0.47) CES2KDM4EALDH1A1HPGDHSD17B10
SCHEMBL1994152 0.71 KDM4E (0.71) CES2KDM4EALDH1A1HPGDHSD17B10
SCHEMBL15453941 0.71 CES2 (0.43) CES2KDM4EALDH1A1HPGDHSD17B10
SCHEMBL7597732 0.71 CES2 (0.43) CES2KDM4EALDH1A1HPGDHSD17B10
SCHEMBL3194189 0.71 CES2 (0.37) CES2KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US claimed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US disclosed
EP-2338935-B1 FLUORINE-CONTAINING COPOLYMER COMPOSITION AND PROCESS FOR PRODUCTION THEREOF ASAHI GLASS CO LTD (JP) 2012-12-12 EP disclosed
US-20110172336-A1 FLUOROCOPOLYMER COMPOSITION AND ITS PRODUCTION PROCESS ASAHI GLASS COMPANY, LIMITED (JP) 2011-07-14 US disclosed
EP-2338935-A1 FLUORINE-CONTAINING COPOLYMER COMPOSITION AND PROCESS FOR PRODUCTION THEREOF ASAHI GLASS COMPANY, LIMITED (JP) 2011-06-29 EP disclosed