Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15871580 | 0.85 | ALDH1A1 (0.34) | SMN1; SMN2ALDH1A1POLBHTT | |
| SCHEMBL15030739 | 0.83 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1POLBHTTKDM4E | |
| SCHEMBL19981541 | 0.80 | USP2 (0.38) | SMN1; SMN2ALDH1A1POLBHTTKDM4E | |
| SCHEMBL20019726 | 0.78 | ATM (0.42) | SMN1; SMN2ALDH1A1KDM4EMEN1LMNA | |
| SCHEMBL25775999 | 0.77 | — | — | |
| SCHEMBL28856427 | 0.74 | — | — | |
| SCHEMBL11559490 | 0.74 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1POLBHTTKDM4E | |
| SCHEMBL20019698 | 0.69 | CA12 (0.33) | TDP1 | |
| SCHEMBL8288442 | 0.69 | TDP1 (0.52) | SMN1; SMN2POLBHTTKMT2ATDP1 | |
| SCHEMBL19981425 | 0.68 | ALDH1A1 (0.34) | SMN1; SMN2ALDH1A1POLBKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788487-B1 | OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-04-04 | — | — | EP | disclosed |
| EP-2788488-B1 | METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-03-21 | — | — | EP | disclosed |