Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20019726 | 0.91 | ATM (0.42) | ALDH1A1SMN1; SMN2HSD17B10KDM4EMEN1 | |
| SCHEMBL15030738 | 0.84 | L3MBTL1 (0.40) | USP2ALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL19981499 | 0.80 | SMN1; SMN2 (0.35) | USP2ALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL20885121 | 0.76 | ALDH1A1 (0.56) | USP2ALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL14654985 | 0.76 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2HSD17B10KDM4EMEN1 | |
| SCHEMBL15871575 | 0.75 | ATM (0.39) | ALDH1A1SMN1; SMN2HSD17B10KDM4EMEN1 | |
| SCHEMBL25775999 | 0.74 | — | — | |
| SCHEMBL3242393 | 0.71 | SMN1; SMN2 (0.51) | USP2ALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL6499575 | 0.71 | TDP1 (0.48) | USP2ALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL408997 | 0.71 | USP2 (0.34) | USP2ALDH1A1SMN1; SMN2HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788487-B1 | OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-04-04 | — | — | EP | disclosed |
| EP-2788488-B1 | METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-03-21 | — | — | EP | disclosed |