Sugi Predict

Sugi Predict / Compounds / SCHEMBL19981509

SCHEMBL19981509

SCHEMBL19981509

CCOC(=O)/C=C/C(=O)Nc1nc(C)c(-c2ccccc2)s1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 9/20 0.55
▸ LMNA P02545 7/20 0.55
▸ RAB9A P51151 4/20 0.55
▸ NPSR1 Q6W5P4 3/20 0.55
▸ HPGD P15428 1/20 0.55
▸ XIAP P98170 1/20 0.54
▸ MAPT P10636 6/20 0.52
▸ MDM2 Q00987 1/20 0.52
▸ HTT P42858 3/20 0.52
▸ THRB P10828 2/20 0.51
▸ CYP1A2 P05177 2/20 0.51
▸ CYP2C9 P11712 2/20 0.51
▸ CYP2C19 P33261 2/20 0.51
▸ HSD17B10 Q99714 1/20 0.51
▸ KDM4E B2RXH2 1/20 0.51
▸ RXFP1 Q9HBX9 1/20 0.51
▸ GSTO1 P78417 1/20 0.50
▸ NPC1 O15118 3/20 0.49
▸ TSHR P16473 1/20 0.49
▸ CLK1 P49759 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23647317 0.89 LMNA (0.50) ALDH1A1LMNARAB9ANPSR1HPGD
SCHEMBL19981496 0.89 LMNA (0.50) ALDH1A1LMNARAB9ANPSR1HPGD
SCHEMBL19981501 0.87 LMNA (0.48) ALDH1A1LMNARAB9ANPSR1HPGD
SCHEMBL19981400 0.87 GAA (0.53) ALDH1A1LMNARAB9ANPSR1HPGD
SCHEMBL19974138 0.85 XIAP (0.61) ALDH1A1LMNARAB9ANPSR1HPGD
SCHEMBL19974136 0.85 XIAP (0.61) ALDH1A1LMNARAB9ANPSR1HPGD
SCHEMBL19981508 0.80 MAPT (0.58) ALDH1A1LMNARAB9ANPSR1HPGD
SCHEMBL19981420 0.79 PARP1 (0.64) ALDH1A1LMNARAB9AHPGDMAPT
SCHEMBL19272762 0.79 GSTO1 (0.60) ALDH1A1LMNARAB9ANPSR1HPGD
SCHEMBL19981570 0.79 NPC1 (0.69) ALDH1A1LMNARAB9AMAPTMDM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3512602-B1 INHIBITORS OF HEAT SHOCK FACTORS (HSF) AND USES THEREOF HSF PHARMACEUTICALS (CH) 2024-03-27 — — EP disclosed
US-11597708-B2 Inhibitors of heat shock factors and uses thereof HSF PHARMACEUTICALS SA (CH) 2023-03-07 — — US disclosed
US-11597708-B2 Inhibitors of heat shock factors and uses thereof HSF PHARMACEUTICALS SA (CH) 2023-03-07 — — US disclosed
US-20210221778-A1 Inhibitors of heat shock factors and uses thereof HSF PHARMACEUTICALS SA (CH) 2021-07-22 — — US disclosed
US-20210221778-A1 Inhibitors of heat shock factors and uses thereof HSF PHARMACEUTICALS SA (CH) 2021-07-22 — — US disclosed
WO-2018050656-A2 INHIBITORS OF HEAT SHOCK FACTORS AND USES THEREOF HSF PHARMACEUTICALS (CH) 2018-03-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11597708-B2 Inhibitors of heat shock factors and uses thereof HSF1, HSP90AB2P, HSP90AB1 ALDH1A1 2641/4885LMNA 3549/4885RAB9A 4035/4885
US-20210221778-A1 Inhibitors of heat shock factors and uses thereof HSF1, HSP90AB2P, HSP90AB1 ALDH1A1 2641/4885LMNA 3549/4885RAB9A 4035/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.