Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.69 |
| ▸ | RAB9A | P51151 | 8/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | STAT1 | P42224 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30271559 | 1.00 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2MAPK1FSCN1 | |
| SCHEMBL8689148 | 0.82 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL3052451 | 0.81 | DYRK1A (0.62) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL3052450 | 0.81 | DYRK1A (0.62) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL19974168 | 0.80 | FSCN1 (0.75) | NPC1RAB9ASMN1; SMN2FSCN1ALDH1A1 | |
| SCHEMBL19974167 | 0.80 | FSCN1 (0.75) | NPC1RAB9ASMN1; SMN2FSCN1ALDH1A1 | |
| SCHEMBL11114010 | 0.80 | NPC1 (0.76) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL19981509 | 0.79 | ALDH1A1 (0.55) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL23647317 | 0.77 | LMNA (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL19981496 | 0.77 | LMNA (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11597708-B2 | Inhibitors of heat shock factors and uses thereof | HSF PHARMACEUTICALS SA (CH) | 2023-03-07 | — | — | US | disclosed |
| US-20210221778-A1 | Inhibitors of heat shock factors and uses thereof | HSF PHARMACEUTICALS SA (CH) | 2021-07-22 | — | — | US | disclosed |
| WO-2018050656-A2 | INHIBITORS OF HEAT SHOCK FACTORS AND USES THEREOF | HSF PHARMACEUTICALS (CH) | 2018-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11597708-B2 | Inhibitors of heat shock factors and uses thereof | HSF1, HSP90AB2P, HSP90AB1 | NPC1 3462/4885RAB9A 4035/4885SMN1; SMN2 4284/4885 |
| US-20210221778-A1 | Inhibitors of heat shock factors and uses thereof | HSF1, HSP90AB2P, HSP90AB1 | NPC1 3462/4885RAB9A 4035/4885SMN1; SMN2 4284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.