Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | GSK3A | P49840 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 4/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13363463 | 0.80 | GSK3A (0.43) | GSK3BGSK3ADYRK1ANPC1RAB9A | |
| SCHEMBL9984648 | 0.73 | BTK (0.49) | NPC1RAB9AMEN1KMT2ABTK | |
| SCHEMBL12045170 | 0.72 | GSK3A (0.41) | GSK3BGSK3ADYRK1ABTKMKNK1 | |
| SCHEMBL2409087 | 0.71 | PIM1 (0.46) | GSK3BGSK3ADYRK1ANPC1RAB9A | |
| SCHEMBL1925367 | 0.68 | ALPL (0.51) | GSK3BRETKDR | |
| SCHEMBL1924983 | 0.68 | ALPL (0.47) | GSK3BNPC1RAB9ACASP3SENP8 | |
| SCHEMBL8415608 | 0.67 | NPC1 (0.56) | GSK3BGSK3ADYRK1ANPC1RAB9A | |
| SCHEMBL12595734 | 0.66 | LMNA (0.60) | GSK3BGSK3ADYRK1AMEN1KMT2A | |
| SCHEMBL19981738 | 0.66 | BTK (0.37) | GSK3BGSK3ADYRK1ARAB9AMEN1 | |
| SCHEMBL14985532 | 0.63 | MAPT (0.46) | GSK3BGSK3ADYRK1ABTKALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |