Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13303500 | 0.79 | UGT2B17 (0.35) | ALDH1A1HPGDSMN1; SMN2PNMTNOS3 | |
| SCHEMBL17970193 | 0.73 | UGT2B17 (0.40) | ALDH1A1HPGDSMN1; SMN2PNMTNOS3 | |
| SCHEMBL18723816 | 0.72 | HTR6 (0.37) | ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL17970195 | 0.69 | PNMT (0.52) | ALDH1A1HPGDSMN1; SMN2PNMTMEN1 | |
| SCHEMBL15276752 | 0.69 | PNMT (0.52) | ALDH1A1HPGDSMN1; SMN2PNMTMEN1 | |
| SCHEMBL25771692 | 0.69 | PNMT (0.52) | ALDH1A1HPGDSMN1; SMN2PNMTMEN1 | |
| SCHEMBL14907201 | 0.69 | PNMT (0.52) | ALDH1A1HPGDSMN1; SMN2PNMTMEN1 | |
| SCHEMBL16230045 | 0.69 | PNMT (0.52) | ALDH1A1HPGDSMN1; SMN2PNMTMEN1 | |
| SCHEMBL21093837 | 0.69 | PNMT (0.52) | ALDH1A1HPGDSMN1; SMN2PNMTMEN1 | |
| SCHEMBL15426775 | 0.69 | PNMT (0.52) | ALDH1A1HPGDSMN1; SMN2PNMTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |