Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.54 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21460559 | 0.82 | APP (0.57) | APPKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1998196 | 0.79 | KDM4E (0.49) | APPNUDT1TLR8TLR7KDM4E | |
| SCHEMBL20219465 | 0.75 | L3MBTL1 (0.61) | NUDT1TLR8TLR7 | |
| SCHEMBL17035546 | 0.74 | TLR8 (0.62) | TLR8TLR7 | |
| SCHEMBL29695687 | 0.73 | BCL6 (0.66) | NUDT1 | |
| SCHEMBL1319424 | 0.73 | BCL6 (0.66) | NUDT1 | |
| SCHEMBL23472149 | 0.73 | TLR8 (0.61) | TLR8TLR7 | |
| SCHEMBL6414963 | 0.73 | TLR7 (0.58) | APPTLR8TLR7 | |
| SCHEMBL18072502 | 0.72 | NUDT1 (0.53) | NUDT1TLR8TLR7SMN1; SMN2NPC1 | |
| SCHEMBL557825 | 0.72 | APP (0.51) | APPNUDT1NPC1RAB9ASLC29A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011076878-A1 | AMINOALKYLPYRIMIDINE DERIVATIVES AS HISTAMINE H4 RECEPTOR ANTAGONISTS | PALAU PHARMA, S.A. (ES) | 2011-06-30 | — | — | WO | disclosed |