Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ASPH | Q12797 | 1/20 | 0.49 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.49 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002467 | 0.92 | HDAC6 (0.53) | KDM4EASPHRIOX2KDM8TLR8 | |
| SCHEMBL1998194 | 0.79 | APP (0.57) | KDM4EF2APPTLR8TLR7 | |
| SCHEMBL23472149 | 0.73 | TLR8 (0.61) | TLR8TLR7 | |
| SCHEMBL10874822 | 0.72 | GAA (0.51) | KDM4ENPC1KDM6BKDM4CRAB9A | |
| SCHEMBL15452392 | 0.71 | BCL6 (0.54) | APPNUDT1LMNAHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28128873 | 0.70 | BCL6 (0.53) | APPNUDT1LMNAHTTSMN1; SMN2 | |
| SCHEMBL1938196 | 0.70 | HTR7 (0.56) | APPGAA | |
| SCHEMBL2451092 | 0.69 | APP (0.64) | APPNUDT1 | |
| SCHEMBL14007511 | 0.69 | BACE1 (0.71) | KDM4EAPPNPC1KDM6BKDM4C | |
| SCHEMBL2002465 | 0.69 | KDM4E (0.42) | KDM4EASPHKDM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011076878-A1 | AMINOALKYLPYRIMIDINE DERIVATIVES AS HISTAMINE H4 RECEPTOR ANTAGONISTS | PALAU PHARMA, S.A. (ES) | 2011-06-30 | — | — | WO | disclosed |