Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 14/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | IL2RA | P01589 | 1/20 | 0.53 |
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | IL2 | P60568 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19982079 | 0.93 | YAP1 (0.73) | YAP1GAAIL2RAALBIL2 | |
| SCHEMBL19982077 | 0.92 | YAP1 (0.55) | YAP1GAAIL2RAALBIL2 | |
| SCHEMBL19982179 | 0.90 | YAP1 (0.59) | YAP1GAAIL2RAALBIL2 | |
| SCHEMBL19976384 | 0.85 | YAP1 (0.69) | YAP1GAAIL2RAALBIL2 | |
| SCHEMBL19976383 | 0.85 | YAP1 (0.69) | YAP1GAAIL2RAALBIL2 | |
| SCHEMBL19982078 | 0.83 | YAP1 (0.72) | YAP1IL2RAALBIL2 | |
| SCHEMBL27389203 | 0.82 | GAA (0.58) | GAAATML3MBTL1CYP3A4CYP2D6 | |
| SCHEMBL19982076 | 0.81 | YAP1 (0.54) | YAP1IL2RAALBIL2 | |
| SCHEMBL19975557 | 0.81 | YAP1 (0.54) | YAP1 | |
| SCHEMBL19982213 | 0.80 | YAP1 (0.85) | YAP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |