Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.34 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19982190 | 0.82 | EGFR (0.46) | TAAR1APPMAPTNPC1RAB9A | |
| SCHEMBL19982272 | 0.82 | TAAR1 (0.43) | TAAR1APPMAPTNPC1RAB9A | |
| SCHEMBL10102686 | 0.81 | TAAR1 (0.60) | TAAR1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL22929156 | 0.81 | MEN1 (0.53) | TAAR1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL19982086 | 0.80 | TAAR1 (0.51) | TAAR1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL19982297 | 0.78 | FBP1 (0.50) | TAAR1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL22929138 | 0.78 | TAAR1 (0.39) | TAAR1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL19982298 | 0.77 | PTGS2 (0.48) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL22929137 | 0.75 | MAOA (0.44) | TAAR1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL19982296 | 0.74 | TLR4 (0.46) | TAAR1MAPTNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |