Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 3/20 | 0.60 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1999248 | 0.88 | MLNR (0.60) | MLNRRETKDRKDM4EKMT2A | |
| SCHEMBL2002475 | 0.87 | MLNR (0.43) | MLNRMAPTKMT2AUSP2ALDH1A1 | |
| SCHEMBL1998238 | 0.81 | MLNR (0.42) | MLNRKDM4EMAPTKMT2ATDP1 | |
| SCHEMBL2853558 | 0.80 | MLNR (0.72) | MLNRPIK3C3KCNH2RORC | |
| SCHEMBL2003110 | 0.80 | MLNR (0.63) | MLNRRETKDRMAPTKMT2A | |
| SCHEMBL1997046 | 0.79 | MEN1 (0.48) | MLNRKDM4EMAPTKMT2AUSP2 | |
| SCHEMBL1998239 | 0.77 | MLNR (0.67) | MLNRKCNH2RORCSETD7 | |
| SCHEMBL377621 | 0.76 | CNR2 (0.36) | RETKDRKDM4ETDP1ALDH1A1 | |
| SCHEMBL1995199 | 0.76 | MLNR (0.58) | MLNRPRKAA2KDM4EMAPTKMT2A | |
| SCHEMBL2004331 | 0.75 | MLNR (1.00) | MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964597-B2 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |