Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 4/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 3/20 | 0.33 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.33 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003110 | 0.92 | MLNR (0.63) | MLNRKMT2ARETKDR | |
| SCHEMBL1995199 | 0.89 | MLNR (0.58) | MLNRHTR2CMCHR1KMT2AKDM4E | |
| SCHEMBL1998242 | 0.88 | MLNR (0.60) | MLNRKMT2AKCNH2PKMKDM4E | |
| SCHEMBL1998238 | 0.86 | MLNR (0.42) | MLNRKMT2APKMKDM4EALDH1A1 | |
| SCHEMBL2849453 | 0.81 | MLNR (0.73) | MLNRKMT2AKCNH2SETD7RORC | |
| SCHEMBL2003279 | 0.80 | PRKAA2 (0.46) | MLNRKMT2AKDM4EUSP2ALDH1A1 | |
| SCHEMBL2002475 | 0.80 | MLNR (0.43) | MLNRKMT2APKMUSP2ALDH1A1 | |
| SCHEMBL2003107 | 0.79 | MLNR (0.47) | MLNRKDM4ERETKDR | |
| SCHEMBL1997046 | 0.79 | MEN1 (0.48) | MLNRKMT2APKMKDM4EUSP2 | |
| SCHEMBL2002729 | 0.79 | MLNR (0.36) | MLNRKMT2AKDM4EALDH1A1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964597-B2 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |