Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003107 | 0.91 | MLNR (0.47) | MLNRKDM4E | |
| SCHEMBL1996929 | 0.88 | KDM4E (0.46) | MLNRKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL1999248 | 0.86 | MLNR (0.60) | MLNRKDM4EALDH1A1KMT2ALMNA | |
| SCHEMBL2002475 | 0.84 | MLNR (0.43) | MLNRALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL1999431 | 0.83 | ALDH1A1 (0.34) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL1998242 | 0.81 | MLNR (0.60) | MLNRKDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL377621 | 0.79 | CNR2 (0.36) | KDM4EALDH1A1TDP1GAA | |
| SCHEMBL2851448 | 0.79 | MLNR (0.52) | MLNRKDM4EALDH1A1DRD2DRD3 | |
| SCHEMBL2003110 | 0.78 | MLNR (0.63) | MLNRKMT2AMAPT | |
| SCHEMBL2003279 | 0.78 | PRKAA2 (0.46) | MLNRKDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964597-B2 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |