Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 10/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19983226 | 0.90 | TDP1 (0.48) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL19982954 | 0.89 | TDP1 (0.53) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL19983029 | 0.84 | TDP1 (0.43) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL25658934 | 0.82 | KMT2A (0.54) | KMT2A | |
| SCHEMBL19983238 | 0.80 | TDP1 (0.52) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL21153191 | 0.79 | TDP1 (0.51) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL26601477 | 0.79 | NPSR1 (0.49) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL19983280 | 0.78 | TDP1 (0.48) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL22460581 | 0.77 | CYP3A4 (0.49) | TDP1ATMNPSR1KMT2AMEN1 | |
| SCHEMBL22460574 | 0.77 | CYP3A4 (0.49) | TDP1ATMNPSR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230142714-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2023-05-11 | — | — | US | disclosed |
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230142714-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | PHYKPL, ENPEP, PREP | TDP1 1585/4885ATM 3237/4885NPSR1 4201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.