Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.56 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2806084 | 0.86 | MKNK1 (0.58) | BAZ2BHDAC6HDAC2HDAC8KCNQ3 | |
| SCHEMBL3955664 | 0.81 | EPHX2 (0.54) | EPHX2HDAC6KCNQ3KCNQ2HDAC1 | |
| SCHEMBL26763421 | 0.80 | GRM5 (0.54) | GRM5EPHX2KCNQ3KCNQ2 | |
| SCHEMBL24554346 | 0.80 | GRM5 (0.54) | GRM5EPHX2KCNQ3KCNQ2 | |
| SCHEMBL12788711 | 0.80 | EPHX2 (0.47) | EPHX2HDAC6KCNQ3KCNQ2HDAC1 | |
| SCHEMBL7962334 | 0.80 | BAZ2B (0.74) | BAZ2BGRM5HDAC6HDAC2HDAC8 | |
| SCHEMBL3952478 | 0.78 | HDAC6 (0.72) | BAZ2BGRM5HDAC6HDAC2HDAC8 | |
| SCHEMBL13184552 | 0.78 | BAZ2B (0.57) | BAZ2BGRM5HDAC6HDAC2HDAC8 | |
| SCHEMBL13451410 | 0.78 | BAZ2B (0.57) | BAZ2BGRM5HDAC6HDAC2HDAC8 | |
| SCHEMBL3613538 | 0.78 | MAOA (0.51) | EPHX2KCNQ3KCNQ2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | disclosed |