Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.48 |
| ▸ | CTSH | P09668 | 4/20 | 0.48 |
| ▸ | CTSL | P07711 | 3/20 | 0.48 |
| ▸ | CTSB | P07858 | 3/20 | 0.48 |
| ▸ | CTSS | P25774 | 3/20 | 0.48 |
| ▸ | CTSF | Q9UBX1 | 2/20 | 0.48 |
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19630778 | 0.86 | CTSK (0.47) | CTSKCTSHCTSLCTSBCTSS | |
| SCHEMBL19983011 | 0.86 | CTSK (0.47) | CTSKCTSHCTSLCTSBCTSS | |
| SCHEMBL19983065 | 0.71 | CTSL (0.47) | CTSKCTSLMEN1ALDH1A1PLG | |
| SCHEMBL22170860 | 0.71 | CTSK (0.45) | CTSKCTSHCTSLCTSBCTSS | |
| SCHEMBL16062078 | 0.66 | MAPT (0.41) | CTSKCTSHCTSLCTSBCTSS | |
| SCHEMBL23695721 | 0.65 | PAOX (0.52) | MEN1ALDH1A1PLGLMNATHRB | |
| SCHEMBL3216951 | 0.65 | MAPT (0.50) | CTSKCTSHCTSLCTSBCTSS | |
| SCHEMBL152548 | 0.65 | LMNA (0.65) | MEN1ALDH1A1PLGLMNATHRB | |
| SCHEMBL28821576 | 0.65 | LMNA (0.65) | MEN1ALDH1A1PLGLMNATHRB | |
| SCHEMBL5193962 | 0.65 | LMNA (0.65) | MEN1ALDH1A1PLGLMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | disclosed |