Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22395413 | 0.81 | P2RX7 (0.64) | P2RX7KDM4ETDP1KMT2AALDH1A1 | |
| SCHEMBL27986290 | 0.81 | MAPK8 (0.47) | P2RX7LMNAPOLBRIPK1KMT2A | |
| SCHEMBL27923137 | 0.81 | CHIA (0.55) | P2RX7LMNARIPK1KDM4EL3MBTL1 | |
| SCHEMBL161745 | 0.79 | GAA (0.48) | GAAP2RX7PLK1LMNAPOLB | |
| SCHEMBL4766191 | 0.79 | P2RX7 (0.71) | GAAP2RX7PLK1LMNAPOLB | |
| SCHEMBL93650 | 0.79 | GAA (0.48) | GAAP2RX7PLK1LMNAPOLB | |
| SCHEMBL365580 | 0.79 | KDM4E (0.45) | P2RX7LMNAKDM4ETDP1L3MBTL1 | |
| SCHEMBL30320721 | 0.79 | KDM4E (0.45) | P2RX7LMNAKDM4ETDP1L3MBTL1 | |
| SCHEMBL2306154 | 0.78 | GAA (0.47) | GAAP2RX7PLK1LMNAPOLB | |
| SCHEMBL9569279 | 0.78 | GAA (0.47) | GAAP2RX7PLK1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | disclosed |
| CN-102958918-B | Novel tobacco amide derivatives or its salt | FUJIFILM CORP. (JP) | 2015-12-09 | — | — | CN | disclosed |
| CN-102574845-B | 1H-imidazo [4,5-c] qualone derivative | NOVARTIS AG (CH) | 2015-09-02 | — | — | CN | disclosed |
| CN-104341416-A | Protein tyrosine kinase inhibitor and application thereof | NANJING SANHOME PHARMACEUTICAL CO LTD | 2015-02-11 | — | — | CN | disclosed |