Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 20/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | CASP1 | P29466 | 1/20 | 0.67 |
| ▸ | CASP7 | P55210 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21589933 | 0.84 | HPGD (0.56) | HPGDKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL22939512 | 0.82 | HPGD (0.69) | HPGDKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL15583810 | 0.81 | HPGD (0.71) | HPGDKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL30701209 | 0.81 | HPGD (0.71) | HPGDKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL27473523 | 0.81 | HPGD (0.70) | HPGDKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL15525575 | 0.81 | HPGD (1.00) | HPGDKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL19416785 | 0.80 | HPGD (0.67) | HPGDKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL21973660 | 0.80 | HPGD (0.80) | HPGDKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL18962635 | 0.79 | HPGD (0.67) | HPGDKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL19416733 | 0.79 | HPGD (0.69) | HPGDKDM4EMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3295940-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | Case Western Reserve University (US) | 2018-03-21 | — | — | EP | disclosed |