Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 19/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | CASP1 | P29466 | 1/20 | 1.00 |
| ▸ | CASP7 | P55210 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 1.00 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15525561 | 0.84 | HPGD (1.00) | HPGDKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL21973488 | 0.84 | HPGD (0.94) | HPGDKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL18165749 | 0.84 | HPGD (0.72) | HPGDKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL21974107 | 0.83 | HPGD (0.93) | HPGDKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL23657607 | 0.83 | HPGD (1.00) | HPGDKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL18153497 | 0.82 | HPGD (0.70) | HPGDKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL22777185 | 0.82 | HPGD (0.75) | HPGDKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL22939512 | 0.81 | HPGD (0.69) | HPGDKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL19983451 | 0.81 | HPGD (0.67) | HPGDKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL18962635 | 0.81 | HPGD (0.67) | HPGDKDM4EALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240043443-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | UNIV CASE WESTERN RESERVE (US) | 2024-02-08 | — | — | US | disclosed |
| US-20230355636-A1 | COMBINATIONS OF 15-PGDH INHIBITORS WITH CORTICOSTEROIDS AND/OR TNF INHIBITORS AND USES THEREOF | UNIV CASE WESTERN RESERVE (US) | 2023-11-09 | — | — | US | disclosed |
| US-20230285402-A1 | Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity | UNIV TEXAS (US) | 2023-09-14 | — | — | US | disclosed |
| US-20230285402-A1 | Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity | UNIV TEXAS (US) | 2023-09-14 | — | — | US | disclosed |
| US-11690847-B2 | Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof | CASE WESTERN RESERVE UNIVERSITY (US) | 2023-07-04 | — | — | US | disclosed |
| US-11690847-B2 | Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof | CASE WESTERN RESERVE UNIVERSITY (US) | 2023-07-04 | — | — | US | disclosed |
| US-20230165883-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING CORONARY DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-06-01 | — | — | US | disclosed |
| US-20230136730-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-05-04 | — | — | US | disclosed |
| US-20230136730-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-05-04 | — | — | US | disclosed |
| US-11426420-B2 | Inhibitors of short-chain dehydrogenase activity for treating coronary disorders | CASE WESTERN RESERVE UNIVERSITY (US) | 2022-08-30 | — | — | US | disclosed |
| US-20170165241-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-06-15 | — | — | US | disclosed |
| US-20170165241-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-06-15 | — | — | US | disclosed |
| WO-2016144958-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING FIBROSIS | CASE WESTERN RESERVE UNIVERSITY (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2015065716-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | CASE WESTERN RESERVE UNIVERSITY (US) | 2015-05-07 | — | — | WO | disclosed |
| US-20150072998-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2015-03-12 | — | — | US | disclosed |
| US-20150072998-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2015-03-12 | — | — | US | disclosed |
| US-20150072998-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2015-03-12 | — | — | US | disclosed |
| EP-2838533-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | Case Western Reserve University (US) | 2015-02-25 | — | — | EP | disclosed |
| WO-2013158649-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | CASE WESTERN RESERVE UNIVERSITY (US) | 2013-10-24 | — | — | WO | disclosed |
| WO-2013158649-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | CASE WESTERN RESERVE UNIVERSITY (US) | 2013-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230136730-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | HPGD, GCDH, HPGDS | HPGD 1/4885KDM4E 3506/4885ALDH1A1 126/4885 |
| US-20170165241-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | HPGD 2/4885KDM4E 3434/4885ALDH1A1 415/4885 |
| US-20230165883-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING CORONARY DISORDERS | GCDH, HPGD, PGD | HPGD 2/4885KDM4E 3034/4885ALDH1A1 118/4885 |
| US-20230285402-A1 | Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity | HPGD, GCDH, HPGDS | HPGD 1/4885KDM4E 3506/4885ALDH1A1 126/4885 |
| US-20230355636-A1 | COMBINATIONS OF 15-PGDH INHIBITORS WITH CORTICOSTEROIDS AND/OR TNF INHIBITORS AND USES THEREOF | HPGD, HPGDS, PTGS1 | HPGD 1/4885KDM4E 4127/4885ALDH1A1 842/4885 |
| US-11426420-B2 | Inhibitors of short-chain dehydrogenase activity for treating coronary disorders | GCDH, HPGD, PGD | HPGD 2/4885KDM4E 3034/4885ALDH1A1 118/4885 |
| US-11690847-B2 | Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof | HPGD, HPGDS, PTGS1 | HPGD 1/4885KDM4E 4259/4885ALDH1A1 972/4885 |
| US-20240043443-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | HPGD 2/4885KDM4E 3434/4885ALDH1A1 415/4885 |
| US-20150072998-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | HPGD 2/4885KDM4E 3434/4885ALDH1A1 415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.