Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19984617 | 0.86 | HTT (0.62) | HSD17B10L3MBTL1PABPC1TDP1POLB | |
| SCHEMBL19984752 | 0.81 | PARP1 (0.41) | HSD17B10L3MBTL1PABPC1TDP1SMN1; SMN2 | |
| SCHEMBL2505469 | 0.77 | HSD17B10 (0.69) | HSD17B10L3MBTL1SMN1; SMN2ALOX15ALDH1A1 | |
| SCHEMBL19984537 | 0.75 | HSD17B10 (0.46) | HSD17B10L3MBTL1PABPC1TDP1POLB | |
| SCHEMBL19984544 | 0.71 | HSD17B10 (0.47) | HSD17B10L3MBTL1PABPC1TDP1POLB | |
| SCHEMBL21291476 | 0.71 | RAB9A (0.40) | TDP1POLBSMN1; SMN2HTTLMNA | |
| SCHEMBL3487973 | 0.67 | POLB (1.00) | HSD17B10L3MBTL1PABPC1TDP1POLB | |
| SCHEMBL750897 | 0.67 | POLB (1.00) | HSD17B10L3MBTL1PABPC1TDP1POLB | |
| SCHEMBL24124669 | 0.65 | POLB (0.70) | HSD17B10L3MBTL1PABPC1TDP1POLB | |
| SCHEMBL19984639 | 0.65 | HSD17B10 (0.48) | HSD17B10L3MBTL1PABPC1TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053157-A1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES, INC. (US) | 2018-03-22 | — | — | WO | disclosed |