Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19984539 | 0.86 | HSD17B10 (0.59) | HTTLMNAHSD17B10ALOX15ALDH1A1 | |
| SCHEMBL2507969 | 0.79 | HSD17B10 (0.93) | HTTLMNAHSD17B10ALOX15ALDH1A1 | |
| SCHEMBL19984555 | 0.78 | ALOX15 (0.60) | HTTLMNAHSD17B10ALOX15ALDH1A1 | |
| SCHEMBL19984752 | 0.78 | PARP1 (0.41) | HTTLMNAHSD17B10ALOX15ALDH1A1 | |
| SCHEMBL19984543 | 0.75 | ALOX15 (0.64) | HTTLMNAHSD17B10ALOX15ALDH1A1 | |
| SCHEMBL29256255 | 0.71 | POLB (0.72) | HTTLMNAALOX15ALDH1A1TSHR | |
| SCHEMBL713441 | 0.70 | HSD17B10 (0.61) | HTTLMNAHSD17B10ALOX15ALDH1A1 | |
| SCHEMBL708632 | 0.70 | HSD17B10 (0.61) | HTTLMNAHSD17B10ALOX15ALDH1A1 | |
| SCHEMBL21905597 | 0.70 | HTT (0.63) | HTTLMNAHSD17B10ALOX15ALDH1A1 | |
| SCHEMBL21972670 | 0.69 | HTT (0.61) | HTTLMNAHSD17B10ALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053157-A1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES, INC. (US) | 2018-03-22 | — | — | WO | disclosed |