Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.59 |
| ▸ | CES2 | O00748 | 1/20 | 0.59 |
| ▸ | CES1 | P23141 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31478208 | 0.88 | LMNA (0.54) | LMNACES2CES1ALDH1A1SMN1; SMN2 | |
| SCHEMBL31478257 | 0.88 | CES2 (0.47) | LMNACES2CES1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3092001 | 0.86 | LMNA (0.57) | LMNACES2CES1ALDH1A1SMN1; SMN2 | |
| SCHEMBL28830240 | 0.85 | LMNA (0.65) | LMNACES2CES1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29110135 | 0.84 | LMNA (0.70) | LMNACES2CES1ALDH1A1SMN1; SMN2 | |
| SCHEMBL27484428 | 0.82 | LMNA (0.58) | LMNACES2CES1ALDH1A1SMN1; SMN2 | |
| SCHEMBL23903947 | 0.81 | CYP2D6 (0.70) | LMNACES2CES1ALDH1A1CYP2D6 | |
| SCHEMBL20511280 | 0.81 | CYP2D6 (0.70) | LMNACES2CES1ALDH1A1CYP2D6 | |
| SCHEMBL11822535 | 0.81 | CYP2D6 (0.70) | LMNACES2CES1ALDH1A1CYP2D6 | |
| SCHEMBL20511263 | 0.81 | CYP2D6 (0.70) | LMNACES2CES1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306986-B1 | PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES | PROLYNX LLC (US) | 2018-03-21 | — | — | EP | disclosed |