SCHEMBL19984832

SCHEMBL19984832

COc1ccccc1-c1nnc(CNSNC(C(=O)O)C(C)O)o1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.47
ALDH1A1 P00352 3/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
NPC1 O15118 1/20 0.46
THRB P10828 1/20 0.46
HPGD P15428 1/20 0.46
MAPK1 P28482 1/20 0.46
RAB9A P51151 1/20 0.46
LMNA P02545 3/20 0.43
GLA P06280 1/20 0.42
EGFR P00533 1/20 0.42
PTK2 Q05397 1/20 0.41
USP2 O75604 1/20 0.40
STAT3 P40763 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
CTSS P25774 1/20 0.40
CTSK P43235 1/20 0.40
ANO1 Q5XXA6 1/20 0.40
ANO2 Q9NQ90 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19984818 0.85 KMT2A (0.47) KMT2AALDH1A1SMN1; SMN2NPC1THRB
SCHEMBL19984969 0.75 CTSS (0.51) KMT2AALDH1A1SMN1; SMN2NPC1THRB
SCHEMBL19984808 0.72 EGFR (0.50) KMT2AALDH1A1SMN1; SMN2NPC1THRB
SCHEMBL19866375 0.71 KMT2A (0.43) KMT2AALDH1A1SMN1; SMN2NPC1THRB
SCHEMBL18078746 0.71 KMT2A (0.43) KMT2AALDH1A1SMN1; SMN2NPC1THRB
SCHEMBL19984797 0.71 KMT2A (0.44) KMT2AALDH1A1SMN1; SMN2NPC1THRB
SCHEMBL19984849 0.70 CTSA (0.43) KMT2AALDH1A1SMN1; SMN2NPC1THRB
SCHEMBL18078745 0.70 VSIR (0.48) KMT2AALDH1A1SMN1; SMN2NPC1THRB
SCHEMBL19866358 0.70 VSIR (0.48) KMT2AALDH1A1SMN1; SMN2NPC1THRB
SCHEMBL18078747 0.70 ADAMTS4 (0.45) KMT2AALDH1A1SMN1; SMN2NPC1THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018051255-A1 CYCLIC SUBSTITUTED-1,3,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) 2018-03-22 WO disclosed