SCHEMBL19985749

SCHEMBL19985749

O[SiH](O)Oc1ccc(Oc2ccccc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 7/20 0.57
TSHR P16473 1/20 0.57
NR1H2 P55055 1/20 0.56
BAX Q07812 1/20 0.56
SRD5A2 P31213 3/20 0.50
CA1 P00915 2/20 0.50
CA2 P00918 2/20 0.50
MAOA P21397 1/20 0.50
PARP10 Q53GL7 1/20 0.47
FFAR1 O14842 1/20 0.42
IDH1 O75874 1/20 0.42
GSTP1 P09211 1/20 0.42
SOS1 Q07889 1/20 0.42
CA9 Q16790 1/20 0.42
PLA2G2A P14555 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL435149 0.79 LTA4H (0.92) LTA4HTSHRNR1H2BAXSRD5A2
SCHEMBL122719 0.79 LTA4H (0.92) LTA4HTSHRNR1H2BAXSRD5A2
SCHEMBL22129853 0.79 LTA4H (0.92) LTA4HTSHRNR1H2BAXSRD5A2
SCHEMBL3893562 0.79 LTA4H (0.92) LTA4HTSHRNR1H2BAXSRD5A2
SCHEMBL11576945 0.79 LTA4H (0.92) LTA4HTSHRNR1H2BAXSRD5A2
SCHEMBL9212518 0.79 LTA4H (0.92) LTA4HTSHRNR1H2BAXSRD5A2
SCHEMBL18105326 0.76 LTA4H (0.57) LTA4HTSHRNR1H2BAXSRD5A2
SCHEMBL19784954 0.76 LTA4H (0.57) LTA4HTSHRNR1H2BAXSRD5A2
Diphenylether SCHEMBL9061108 0.76 LTA4H (1.00) LTA4HTSHRNR1H2BAXSRD5A2
Diphenylether SCHEMBL12286 0.76 LTA4H (1.00) LTA4HTSHRNR1H2BAXSRD5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10435420-B2 High-RI siloxane monomers, their polymerization and use INKRON OY (FI) 2019-10-08 US disclosed
US-20180079761-A1 High-RI siloxane monomers, their polymerization and use INKRON OY (FI) 2018-03-22 US disclosed
US-20180079761-A1 High-RI siloxane monomers, their polymerization and use INKRON OY (FI) 2018-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10435420-B2 High-RI siloxane monomers, their polymerization and use IPO9, PPOX, PPID LTA4H 1437/4885TSHR 4556/4885NR1H2 407/4885
US-20180079761-A1 High-RI siloxane monomers, their polymerization and use IPO9, PPOX, PPID LTA4H 1437/4885TSHR 4556/4885NR1H2 407/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.