Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25359893 | 0.89 | L3MBTL1 (0.47) | L3MBTL1HDAC8ALDH1A1 | |
| SCHEMBL20713609 | 0.85 | GBA1 (0.35) | L3MBTL1 | |
| SCHEMBL18641909 | 0.82 | L3MBTL1 (0.38) | L3MBTL1ALDH1A1 | |
| SCHEMBL30911488 | 0.81 | SLC6A4 (0.39) | TLR7ALDH1A1POLB | |
| SCHEMBL4612485 | 0.81 | — | — | |
| SCHEMBL19438892 | 0.81 | PDK2 (0.33) | L3MBTL1 | |
| SCHEMBL30911491 | 0.78 | MAPT (0.33) | HDAC8 | |
| SCHEMBL27407689 | 0.78 | KIT (0.36) | L3MBTL1HDAC8 | |
| SCHEMBL5796848 | 0.77 | CYP19A1 (0.39) | L3MBTL1ALDH1A1 | |
| SCHEMBL30911847 | 0.77 | FLT3 (0.34) | L3MBTL1HDAC8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512853-B1 | FUSED 1,4-DIAZEPINES AS BET PROTEIN DEGRADERS | UNIV MICHIGAN REGENTS (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2018052949-A1 | FUSED 1,4-DIAZEPINES AS BET PROTEIN DEGRADERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-03-22 | — | — | WO | disclosed |