Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | CDC25B | P30305 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5998647 | 0.86 | NOTUM (0.41) | CYP19A1MAPK14LGALS3 | |
| SCHEMBL24878799 | 0.79 | CYP19A1 (0.40) | CYP19A1MAPK14POLB | |
| SCHEMBL22854013 | 0.77 | CYP19A1 (0.39) | CYP19A1POLB | |
| SCHEMBL908039 | 0.77 | ALDH1A1 (0.41) | MAPK14ALDH1A1POLBHTTATM | |
| SCHEMBL24878496 | 0.76 | CYP19A1 (0.39) | CYP19A1MAPK14POLB | |
| SCHEMBL22854014 | 0.75 | CYP19A1 (0.38) | CYP19A1POLBHTTATM | |
| SCHEMBL13872394 | 0.75 | ALDH1A1 (0.40) | MAPK14ALDH1A1HTTATM | |
| SCHEMBL20926022 | 0.74 | CYP19A1 (0.40) | CYP19A1POLB | |
| SCHEMBL19901549 | 0.74 | CYP19A1 (0.44) | CYP19A1POLB | |
| SCHEMBL24974351 | 0.74 | CYP19A1 (0.40) | CYP19A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053517-A1 | INHIBITORS OF LDLR-PCSK9 PROTEIN-PROTEIN INTERACTION AND METHODS OF THEIR USE | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2018-03-22 | — | — | WO | disclosed |