Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ME2 | P23368 | 2/20 | 0.40 |
| ▸ | ME1 | P48163 | 2/20 | 0.40 |
| ▸ | ME3 | Q16798 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2312197 | 0.80 | GPR119 (0.52) | GPR119ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL26077367 | 0.80 | ALDH1A1 (0.54) | GPR119ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL2002031 | 0.79 | HRH3 (0.47) | GPR119ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL11909895 | 0.78 | CHRM4 (0.46) | ALDH1A1RAB9AMAPTSMN1; SMN2LMNA | |
| SCHEMBL1998372 | 0.78 | GPR119 (0.46) | GPR119MAPTLMNAKDM4EME2 | |
| SCHEMBL2000005 | 0.78 | HRH3 (0.48) | GPR119ALDH1A1MAPTLMNACHRM4 | |
| SCHEMBL21564567 | 0.78 | CKS1B (0.60) | GPR119ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL30931783 | 0.78 | CKS1B (0.60) | GPR119ALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL1998673 | 0.78 | GPR119 (0.54) | GPR119ALDH1A1SMN1; SMN2KDM4EHSD17B10 | |
| Acetic Acid SCHEMBL27439012 | 0.78 | P4HTM (0.53) | GPR119ALDH1A1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575586-A1 | 2-PYRIDYL AND 2-PYRIMIDYL CYCLOALKYLENE AMIDE COMPOUNDS AS NR2B RECEPTOR ANTAGONISTS | Pfizer Japan Inc. (JP) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004054579-A1 | 2-PYRIDYL AND 2-PYRIMIDYL CYCLOALKYLENE AMIDE COMPOUNDS AS NR2B RECEPTOR ANTAGONISTS | PFIZER JAPAN INC. (JP) | 2004-07-01 | — | — | WO | disclosed |