Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | DHFR | P00374 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19986847 | 0.82 | KMT2A (0.68) | MEN1KMT2ADHFRALDH1A1LMNA | |
| SCHEMBL17208719 | 0.79 | MEN1 (0.45) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL17208694 | 0.76 | HDAC8 (0.42) | MEN1KMT2AHTTCYP3A4 | |
| SCHEMBL19986857 | 0.75 | KIT (0.43) | MEN1KMT2A | |
| SCHEMBL14704861 | 0.70 | MEN1 (1.00) | MEN1KMT2ADHFRALDH1A1LMNA | |
| SCHEMBL14704868 | 0.69 | MEN1 (0.62) | MEN1KMT2AALDH1A1LMNAGAA | |
| SCHEMBL807843 | 0.68 | MEN1 (0.49) | MEN1KMT2ANOS3NOS2 | |
| SCHEMBL19986922 | 0.68 | MEN1 (0.47) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9363410 | 0.67 | RAPGEF4 (0.52) | MEN1KMT2AALDH1A1LMNAGAA | |
| SCHEMBL5608865 | 0.66 | HDAC8 (0.59) | MEN1KMT2AALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2018-03-21 | — | — | EP | disclosed |