Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19986835 | 0.82 | MEN1 (0.54) | KMT2AMEN1HTTMAPTALDH1A1 | |
| SCHEMBL14704861 | 0.81 | MEN1 (1.00) | KMT2AMEN1ADRA2CMAPTALDH1A1 | |
| SCHEMBL14704868 | 0.77 | MEN1 (0.62) | KMT2AMEN1ALDH1A1LMNAGAA | |
| SCHEMBL19986922 | 0.76 | MEN1 (0.47) | KMT2AMEN1HTTALDH1A1ALOX12 | |
| SCHEMBL2397579 | 0.73 | GAA (0.60) | KMT2AMEN1ADRA2CHTTMAPT | |
| SCHEMBL807843 | 0.70 | MEN1 (0.49) | KMT2AMEN1 | |
| SCHEMBL10885162 | 0.70 | ADRA2C (0.51) | KMT2AMEN1ADRA2CHTTMAPT | |
| SCHEMBL5134065 | 0.69 | MEN1 (0.53) | KMT2AMEN1POLBCYP1A2CYP2D6 | |
| SCHEMBL6469053 | 0.69 | CASR (0.50) | KMT2AMEN1HTTALDH1A1LMNA | |
| SCHEMBL28046517 | 0.67 | MAPT (0.60) | KMT2AMEN1ADRA2CHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2018-03-21 | — | — | EP | disclosed |