Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 12/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | FES | P07332 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | FER | P16591 | 1/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.42 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.42 |
| ▸ | CSK | P41240 | 1/20 | 0.42 |
| ▸ | ABL2 | P42684 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31290944 | 0.86 | ROCK2 (0.49) | METROCK2MAP3K7MAP4K2BRD4 | |
| SCHEMBL24885851 | 0.86 | ROCK2 (0.49) | METROCK2MAP3K7MAP4K2BRD4 | |
| SCHEMBL31061568 | 0.81 | MAP3K7 (0.53) | METROCK2MAP3K7MAP4K2MAPK14 | |
| SCHEMBL10125124 | 0.75 | AURKB (0.51) | MAP4K2BRD4MAP4K4KDRPRKCI | |
| SCHEMBL4819914 | 0.74 | MET (0.48) | METROCK2MAPK14KDRPRKCI | |
| SCHEMBL29424797 | 0.73 | BRD4 (0.60) | METMAP4K2BRD4MAP4K4KDR | |
| SCHEMBL298491 | 0.73 | BRD4 (0.60) | METMAP4K2BRD4MAP4K4KDR | |
| SCHEMBL18725649 | 0.72 | ROCK1 (0.53) | SRCKDRPRKCIAXL | |
| SCHEMBL29827142 | 0.72 | ROCK1 (0.53) | SRCKDRPRKCIAXL | |
| SCHEMBL3485162 | 0.72 | ROCK2 (0.52) | METROCK2PRKCIAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2018-03-21 | — | — | EP | disclosed |